CEA Paris-SACLAY has published a preclinical study on SULFODYNE^®, a broccoli seed extract stabilised at 5% active and natural sulforaphane. The purpose of the preclinical in vitro and in vivo study was to investigate the effects of SULFODYNE^® on the symptoms associated with SARS-CoV-2 virus infection. The study demonstrates the link between activation of the Nrf2 pathway and the associated beneficial effects on viral symptoms.

• Activation of Nrf2 pathway expression: promotes the restoration and activation of the expression of antioxidant and cytoprotective genes and reduces oxidative stress induced by viral infection.
• Antiviral activity: inhibition of viral replication
• Immunomodulatory activity: repression of genes that are over-expressed during viral infection. The immune system response that produces symptoms such as fever, extreme, pain, etc., is attenuated, and recovery is promoted.
  - In vitro results have been confirmed by in vivo results.

These results confirm the benefits of SULFODYNE^® in the area of immunity, thanks to its multiple mechanisms of action which help to reduce the symptoms of viral infections and thus improve recovery.

Reference
Romeo et al.,2024, “Multiple Mechanisms of Action of Sulfodyne^®, a Natural Antioxidant, against Pathogenic Effects of SARS-CoV-2 Infection.”

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